臺北醫學大學　醫學科學研究所　博士　自2006/09至2012/01

中山醫學大學　視光學系　學士　自2002/09至2006/06

臺北醫學大學附設醫院　研究部　醫學研究員　自2015/05至2023/07

臺北醫學大學　醫學系藥理學科　副教授　自2020/02至2023/07

美國維吉尼亞大學　醫學院　訪問學者　自2018/09至2018/10

臺北醫學大學　醫學系藥理學科　助理教授　自2016/03至2020/01

臺北醫學大學　保健營養學系　博士後研究員　自2012/01至2015/04

馬偕醫學院 視光學系 副教授 自2023/08至今

視光學、眼疾病學、生物化學、藥理學

眼疾病學、心血管疾病、新藥開發、血栓與凝血

1. Lin KH, Li JY, Chen RJ, Chen TY, Hsu SH, Wang HH, Peng HY, Sun YY, Lu WJ*.  Paclitaxel exerts antiplatelet and antithrombotic activities: Additional benefit from use of paclitaxel-coated balloons and -eluting stents in coronary revascularization and prevention of in-stent restenosis. THROMBOSIS RESEARCH. Vol.225:63-72. May. 2023. (SCI/SCIE)
2. Lu WJ, Tsai CH, Chen RJ, Huang LT, Chen TY, Chen LC, Wang HH, Peng HY, Sun YY, Lin KH.  Artesunate as a glycoprotein VI antagonist for preventing platelet activation and thrombus formation. BIOMEDICINE & PHARMACOTHERAPY. Vol.153:e113531. Sep. 2022. (SCI/SCIE)
3. Chang Y, Huang WC, Hsu CY, Hsia CW, Jayakumar T, Hsieh CY, Lu WJ*, Chang CC.  Metformin Serves as a Novel Drug Treatment for Arterial Thrombosis: Inhibitory Mechanisms on Collagen-Induced Human Platelet Activation. Applied Sciences-Basel. Vol.12-No.15:e7426. Jul. 2022. (SCI/SCIE)
4. Lee TY, Lu WJ, Changou CA, Hsiung YC, Trang NTT, Lee CY, Chang TH, Jayakumar T, Hsieh CY, Yang CH, Chang CC, Chen RJ, Sheu JR, Lin KH.  Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK/MTOR to sphingolipid metabolism. Autophagy. Vol.17-No.12:4141-4158. Dec. 2021. (SCI/SCIE)
5. Hsia CH, Jayakumar T, Lu WJ, Sheu JR, Hsia CW, Bhavan PS, Manubolu M, Huang WC, Chang Y.  Auraptene, a Monoterpene Coumarin, Inhibits LTA-Induced Inflammatory Mediators via Modulating NF-κB/MAPKs Signaling Pathways. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. Vol.2021:e5319584. Nov. 2021. (SCI/SCIE)
6. Shih TL, Lin KH, Chen RJ, Chen TY, Kao WT, Liu JW, Wang HH, Peng HY, Sun YY, Lu WJ*.  A novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. Vol.25-No.19:9434-9446. Oct. 2021. (SCI/SCIE)
7. Lien LM, Lu WJ, Lin KH, Kang LH, Chen TY, Lin BJ, Lu YC, Huang CY, Shih CM, Chen H, Tsai YC, Chen RJ, Sheu JR.  Influence of vincristine, clinically used in cancer therapy and immune thrombocytopenia, on the function of human platelets. MOLECULES. Vol.26-No.17:e5340. Sep. 2021. (SCI/SCIE)
8. Ko WC, Tsai CT, Hsu KC, Cheng YC, Lin TE, Chen YL, Hong CY, Lu WJ, Shih CM, Yen TL.  Magnolol, a novel antagonist of thrombin and PAR-1, inhibits thrombin-induced connective tissue growth factor (CTGF) expression in vascular smooth muscle cells and ameliorate pathogenesis of restenosis in rats. Applied Sciences-Basel. Vol.10-No.23:e8729. Dec. 2020. (SCI/SCIE)
9. Lien LM, Lu WJ, Chen TY, Lee TY, Wang HH, Peng HY, Chen RJ, Lin KH.  Phospholipase D1 and D2 Synergistically Regulate Thrombus Formation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Vol.21-No.18:e6954. Sep. 2020. (SCI/SCIE)
10. Lu WJ, Li JY, Chen RJ, Huang LT, Lee TY, Lin KH.  VAS2870 and VAS3947 attenuate platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC. Scientific Reports. Vol.9-No.1:e18852. Dec. 2019. (SCI/SCIE)
11. Hsia CW, Tsai CL, Sheu JR, Lu WJ, Hsia CH, Velusamy M, Jayakumar T, Li JY.  Suppression of Human Platelet Activation via Integrin αIIbβ3 Outside-In Independent Signal and Reduction of the Mortality in Pulmonary Thrombosis by Auraptene. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Vol.20-No.22:e5585. Nov. 2019. (SCI/SCIE)
12. Li JY, Chen RJ, Huang LT, Lee TY, Lu WJ*, Lin KH.  Embelin as a novel inhibitor of PKC in the prevention of platelet activation and thrombus formation. Journal of Clinical Medicine. Vol.8-No.10:e1724. Oct. 2019. (SCI/SCIE)
13. Lu WJ, Lin KH, Tseng MF, Yuan KC, Huang HC, Sheu JR, Chen RJ.  New therapeutic strategy of hinokitiol in haemorrhagic shock-induced liver injury. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. Vol.23-No.3:1723-1734. Mar. 2019. (SCI/SCIE)
14. Lu WJ, Chung CL, Chen RJ, Huang LT, Lien LM, Chang CC, Lin KH, Sheu JR.  An antithrombotic strategy by targeting phospholipase D in human platelets. Journal of Clinical Medicine. Vol.7-No.11:e440. Nov. 2018. (SCI/SCIE)
15. Lu WJ, Wu GJ, Chen RJ, Chang CC, Lien LM, Chiu CC, Tseng MF, Huang LT, Lin KH.  Licochalcone A attenuates glioma cell growth in vitro and in vivo through cell cycle arrest. Food & Function. Vol.9-No.8:4500-4507. Aug. 2018. (SCI/SCIE)
16. Hsia CH, Lu WJ, Lin KH, Chou DS, Geraldine P, Jayakuma T, Chang NC, Sheu JR.  Norcantharidin, a clinical used chemotherapeutic agent, acts as a powerful inhibitor by interfering with fibrinogen-integrin αIIbβ3 binding in human platelets. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. Vol.22-No.4:2142-2152. Apr. 2018. (SCI/SCIE)
17. Chang Y, Hsu WH, Yang WB, Jayakumar T, Lee TY, Sheu JR, Lu WJ*, Li JY.  Structure-activity relationship of three synthesized benzimidazole-based oligosaccharides in human platelet activation. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. Vol.40-No.5:1520-1528. Nov. 2017. (SCI/SCIE)
18. Yao WC, Yuan LT, Yang WB, Hsia CH, Huang LT, Lee TY, Sheu JR, Lu WJ, Jayakumar T, Chen RJ.  Development of Benzimidazole Derivatives as Novel Anti-platelet Drugs. CURRENT PHARMACEUTICAL BIOTECHNOLOGY. Vol.18-No.7:594-605. Aug. 2017. (SCI/SCIE)
19. Hsia CH, Velusamy M, Sheu JR, Khamrang T, Jayakumar T, Lu WJ, Lin KH, Chang CC.  A novel ruthenium (II)-derived organometallic compound, TQ-6, potently inhibits platelet aggregation: Ex vivo and in vivo studies. Scientific Reports. Vol.7-No.1:e9556. Aug. 2017. (SCI/SCIE)
20. Lien LM, Lin KH, Huang LT, Tseng MF, Chiu HC, Chen RJ, Lu WJ*.  Licochalcone A prevents platelet activation and thrombus formation through the inhibition of PLCγ2-PKC, Akt, and MAPK pathways. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Vol.18-No.7:e1500. Jul. 2017. (SCI/SCIE)
21. Jayakumar T, Lin KC, Lu WJ, Lin CY, Pitchairaj G, Li JY, Sheu JR.  Nobiletin, a citrus flavonoid, activates vasodilator-stimulated phosphoprotein in human platelets through non-cyclic nucleotide-related mechanisms. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. Vol.39-No.1:174-182. Jan. 2017. (SCI/SCIE)
22. Lee TY, Chang CC, Lu WJ, Yen TL, Lin KH, Geraldine P, Li JY, Sheu JR.  Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies. Scientific Reports. Vol.7:e40002. Jan. 2017. (SCI/SCIE)
23. Yen TL, Chen RJ, Jayakumar T, Lu WJ, Hsieh CY, Hsu MJ, Yang CH, Chang CC, Lin YK, Lin KH, Sheu JR.  Andrographolide stimulates p38 MAPK-Nrf2-HO-1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats. Translational Research. Vol.170:57-72. Apr. 2016. (SCI/SCIE)
24. Yen TL, Wu MP, Chung CL, Yang WB, Jayakumar T, Geraldine P, Chou CM, Chang CY, Lu WJ*, Sheu JR.  Novel synthetic benzimidazole-derived oligosaccharide, M3BIM, prevents ex vivo platelet aggregation and in vivo thromboembolism. JOURNAL OF BIOMEDICAL SCIENCE. Vol.23:e26. Feb. 2016. (SCI/SCIE)
25. Lu WJ, Lin KC, Liu CP, Lin CY, Wu HC, Chou DS, Geraldine P, Huang SY, Hsieh CY, Sheu JR.  Prevention of arterial thrombosis by nobiletin: In vitro and in vivo studies. JOURNAL OF NUTRITIONAL BIOCHEMISTRY. Vol.28:1-8. Feb. 2016. (SCI/SCIE)
26. Lien LM, Wang MJ, Chen RJ, Chiu HC, Wu JL, Shen MY, Sheu JR, Lin KH, Lu WJ*.  Nobiletin, a polymethoxylated flavone, inhibits glioma cell growth and migration via arresting cell cycle and suppressing MAPK and Akt pathways. PHYTOTHERAPY RESEARCH. Vol.30:214-221. Feb. 2016. (SCI/SCIE)
27. Lin KH, Lin KC, Lu WJ, Thomas PA, Jayakumar T, Sheu JR.  Astaxanthin, a carotenoid, stimulates immune responses by enhancing IFN-γ and IL-2 secretion in primary cultured lymphocytes in vitro and ex vivo. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Vol.17:e44. Dec. 2015. (SCI/SCIE)
28. Guo YR, Hsu YH, Liang A, Lu WJ, Wu CH, Lee HC, Huang SY.  n-3 Polyunsaturated fatty acids ameliorate cognitive age-related impairments and depressive behaviour in unchallenged aged prediabetic rats. Journal of Functional Foods. Vol.19:522-536. Dec. 2015. (SCI/SCIE)
29. Lu WJ*, Chang CC, Lien LM, Yen TL, Chiu HC, Huang SY, Sheu JR, Lin KH.  Xanthohumol from Humulus lupulus L. induces glioma cell autophagy via inhibiting Akt/mTOR/S6K pathway. Journal of Functional Foods. Vol.18:538-549. Oct. 2015. (SCI/SCIE)
30. Chung CL, Leung KW, Lu WJ, Yen TL, He CF, Sheu JR, Lin KH, Lien LM.  Hinokitiol negatively regulates immune responses through cell cycle arrest in concanavalin A-activated lymphocytes. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. Vol.2015:e595824. Aug. 2015. (SCI/SCIE)
31. Chang Y, Hsu WH, Lu WJ, Jayakumar T, Liao JC, Lin MJ, Wang SH, Geraldine P, Lin KH, Sheu JR.  Inhibitory mechanisms of CME-1, a novel polysaccharide from the mycelia of Cordyceps sinensis, in platelet activation. CURRENT PHARMACEUTICAL BIOTECHNOLOGY. Vol.16:451-461. Mar. 2015. (SCI/SCIE)
32. Lu WJ, Chang NC, Jayakumar T, Liao JC, Lin MJ, Wang SH, Chou DS, Thomas PA, Sheu JR.  Ex vivo and in vivo studies of CME-1, a novel polysaccharide purified from the mycelia of Cordyceps sinensis that inhibits human platelet activation by activating adenylate cyclase/cyclic AMP. THROMBOSIS RESEARCH. Vol.134:1301-131. Dec. 2014. (SCI/SCIE)
33. Lien LM, Chen ZC, Chung CL, Yen TL, Chiu HC, Chou DS, Huang SY, Sheu JR, Lu WJ*, Lin KH.  Multidrug resistance protein 4 (MRP4/ABCC4) regulates thrombus formation in vitro and in vivo. EUROPEAN JOURNAL OF PHARMACOLOGY. Vol.737:159-167. Aug. 2014. (SCI/SCIE)
34. Chen YY, Hsieh CY, Jayakumar T, Lin KH, Chou DS, Lu WJ, Hsu MJ, Sheu JR.  Andrographolide induces vascular smooth muscle cell apoptosis through a SHP-1-PP2A-p38MAPK-p53 cascade. Scientific Reports. Vol.4:e5651. Jul. 2014. (SCI/SCIE)
35. Lu WJ, Lin KC, Huang SY, Thomas PA, Wu YH, Wu HC, Lin KH, Sheu JR.  Role of a Janus kinase 2-dependent signaling pathway in platelet activation. THROMBOSIS RESEARCH. Vol.133:1088-1096. Jun. 2014. (SCI/SCIE)
36. Lin KH, Lu WJ, Wang SH, Fong TH, Chou DS, Chang CC, Chang NC, Chiang YC, Huang SY, Sheu JR.  Characteristics of endogenous γ-aminobutyric acid (GABA) in human platelets: functional studies of a novel collagen glycoprotein VI inhibitor. JOURNAL OF MOLECULAR MEDICINE. Vol.92:603-614. Jun. 2014. (SCI/SCIE)
37. Yen TL, Lu WJ, Lien LM, Thomas PA, Lee TY, Chiu HC, Lin KH.  Amarogentin, a secoiridoid glycoside, abrogates platelet activation through PLC γ 2-PKC and MAPK pathways. Biomed Research International. Vol.2014:e728019. Apr. 2014. (其他具同儕審查機制之期刊)
38. Lu WJ, Wu MP, Lin KH, Lin YC, Chou HC, Sheu JR.  Hinokitiol is a novel glycoprotein VI antagonist on human platelets. Platelets. Vol.25:595-602. Jan. 2014. (SCI/SCIE)
39. Lien LM, Su CC, Hsu WH, Lu WJ, Chung CL, Yen TL, Chiu HC, Sheu JR, Lin KH.  Mechanisms of andrographolide-induced platelet apoptosis in human platelets: regulatory roles of the extrinsic apoptotic pathway. PHYTOTHERAPY RESEARCH. Vol.27:1671-1677. Nov. 2013. (SCI/SCIE)
40. Yen TL, Hsu WH, Huang SK, Lu WJ, Chang CC, Lien LM, Hsiao G, Sheu JR, Lin KH.  A novel bioactivity of andrographolide from Andrographis paniculata on cerebral ischemia/reperfusion-induced brain injury through induction of cerebral endothelial cell apoptosis. PHARMACEUTICAL BIOLOGY. Vol.51:1150-1157. Sep. 2013. (SCI/SCIE)
41. Jayakumar T, Chen WF, Lu WJ, Chou DS, Hsiao G, Hsu CY, Sheu JR, Hsieh CY.  A novel antithrombotic effect of sulforaphane via activation of platelet adenylate cyclase: ex vivo and in vivo studies. JOURNAL OF NUTRITIONAL BIOCHEMISTRY. Vol.24:1086-1095. Jun. 2013. (SCI/SCIE)
42. Lin KH, Kuo JR, Lu WJ, Chung CL, Chou DS, Huang SY, Lee HC, Sheu JR.  Hinokitiol inhibits platelet activation ex vivo and thrombus formation in vivo. BIOCHEMICAL PHARMACOLOGY. Vol.85:1478-1485. May. 2013. (SCI/SCIE)
43. Chang Y, Huang SK, Lu WJ, Chung CL, Chen WL, Lu SH, Lin KH, Sheu JR.  Brazilin isolated from Caesalpinia sappan L. acts as a novel collagen receptor agonist in human platelets. JOURNAL OF BIOMEDICAL SCIENCE. Vol.20:e4. Jan. 2013. (SCI/SCIE)
44. Lu WJ, Lin KH, Hsu MJ, Chou DS, Hsiao G, Sheu JR.  Suppression of NF-κB signaling by andrographolide with a novel mechanism in human platelets: regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade. BIOCHEMICAL PHARMACOLOGY. Vol.84:914-924. Oct. 2012. (SCI/SCIE)
45. Lee YM, Hsieh KH, Lu WJ, Chou HC, Chou DS, Lien LM, Sheu JR, Lin KH.  Xanthohumol, a prenylated flavonoid from hops (humulus lupulus), prevents platelet activation in human platelets. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. Vol.2012:e852362. May. 2012. (SCI/SCIE)
46. Yen TL, Hsu CK, Lu WJ, Hsieh CY, Hsiao G, Chou DS, Wu GJ, Sheu JR.  Neuroprotective effects of xanthohumol, a prenylated flavonoid from hops (humulus lupulus), in ischemic stroke of rats. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. Vol.60:1937-1944. Feb. 2012. (SCI/SCIE)
47. Chang CC, Lu WJ, Ong ET, Chiang CW, Lin SC, Huang SY, Sheu JR.  A novel role of sesamol in inhibiting NF-kappaB-mediated signaling in platelet activation. JOURNAL OF BIOMEDICAL SCIENCE. Vol.18:e93. Dec. 2011. (SCI/SCIE)
48. Lu WJ, Lee JJ, Chou DS, Jayakumar T, Fong TH, Hsiao G, Sheu JR.  A novel role of andrographolide, an NF-kappa B inhibitor, on inhibition of platelet activation: the pivotal mechanisms of endothelial nitric oxide synthase/cyclic GMP. JOURNAL OF MOLECULAR MEDICINE. Vol.89:1261-1273. Dec. 2011. (SCI/SCIE)
49. Chang CC, Lu WJ, Chiang CW, Jayakumar T, Ong ET, Hsiao G, Fong TH, Chou DS, Sheu JR.  Potent antiplatelet activity of sesamol in an in vitro and in vivo model: pivotal roles of cyclic AMP and p38 mitogen-activated protein kinase. JOURNAL OF NUTRITIONAL BIOCHEMISTRY. Vol.21:1214-1221. Dec. 2010. (SCI/SCIE)
50. Lin KH, Chang HC, Lu WJ, Jayakumar T, Chou HC, Fong TH, Hsiao G, Sheu JR.  Comparison of the relative activities of inducing platelet apoptosis stimulated by various platelet-activating agents. Platelets. Vol.20:575-581. Dec. 2009. (SCI/SCIE)

1. Chia HP, Lin KH, Lee TY, Chen RJ, Lu WJ*.  Aucklandia lappa root extracts suppress platelet activation through the inhibition of PLCγ2-PKC, Akt, and MAPK pathways. 19th World Congress of Basic & Clinical Pharmacology. Jul. 2023.
2. Chen TY, Chen RJ, Lin KH, Lu WJ*.  Formononetin attenuates platelet activation through the inhibition of Akt and PKC pathways. 44th congress of the Japanese society on thrombosis and hemostasis. Jun. 2022.
3. Lu WJ, Kang LH, Lin KH, Chen RJ, Sheu JR.  Vincristine inhibits platelet activation via suppressing Akt and MAPK phosphorylation. 14th Asia Pacific Federation of Pharmacologists. Nov. 2021.
4. Chen RJ, Lin KH, Chen MC, Lu WJ*.  Licochalcone A inhibits melanoma cell growth and migration via arresting cell cycle and suppressing Akt phosphorylation. 44th FEBS Congress. Jul. 2019.
5. Lu WJ*, Lin KH, Chen RJ.  GABA potently inhibits platelet activation: Ex vivo and in vivo studies. 5th World Parkinson Congress. Jun. 2019.
6. Lu WJ*, Lin KH, Chen RJ.  Physiological function of phospholipase D isoform in human and mouse platelets. XXXVII World Congress of International Society of Hematology. Sep. 2018.
7. Chen RJ, Lin KH, Lu WJ*.  Regulatory roles of phospholipase D1 and 2 in human and mouse platelets. 25th Biennial International Congress on Thrombosis. May. 2018.
8. Chen RJ, Lee TY, Lu WJ*.  Functional ex vivo and in vivo studies of honokiol inhibits platelet activation. 19th International Vascular Biology Meeting. Oct. 2016.
9. Chen RJ, Sheu JR, Yang WB, Lu WJ*.  Ex vivo and in vivo studies of M3BIM, a synthetic benzimidazole-derived maltotriose that inhibits platelet activation. 60th Annual Meeting of the Society of Thrombosis and Haemostasis Research. Feb. 2016.
10. Lu WJ*, Huang SY, Sheu JR, Lin KH.  Hinokitiol regulates immune responses through cell cycle arrest in stimulated T lymphocytes. 2015 Annual Main Meeting of the Society for Experimental Biology. Jun. 2015.
11. Lu WJ*, Lee TY, Huang SY, Lin KH.  Nobiletin, a polymethoxy flavone, suppresses glioma cell growth through the inhibition of cell cycle. FEBS-EMBO 2014 Conference. Aug. 2014.
12. Lu WJ, Huang SY, Sheu JR.  Inhibitory role of andrographolide in vascular smooth muscle cell proliferation and cerebral endothelial cell inflammation. 10th World Congress on Brain Injury. Mar. 2014.