國立陽明大學微生物及免疫學研究所博士 
國立陽明大學微生物及免疫學研究所碩士

長庚大學醫學院/生物醫學研究所博士後研究員

微生物及免疫學、藥物活性評估、腫瘤生物學

免疫代謝體學、免疫細胞治療、腫瘤微環境

1. Lin HA, Lin HC, Chen LC, Huang KY, Guo JL.  Applying a multi-faceted infection control strategy to improve hospital environmental cleaning quality. Heliyon. Vol.10-No.3:e24928. Jan. 2024. (SCI/SCIE)
2. Li Z, Peng HY, Lee CS, Lin TB, Hsieh MC, Lai CY, Wu HF, Chen LC, Chen MC, Chou D.  Methylone produces antidepressant-relevant actions and prosocial effects. NEUROPHARMACOLOGY. Vol.242:e109787. Jan. 2024. (SCI/SCIE) ( SDGs3)
3. Chen LC, Chen YJ, Lin HA, Chien WC, Tsai KJ, Chung CH, Wang JY, Chen CC, Liao NS, Shih CT, Lin YY, Huang CN, Ojcius DM, Huang KY, Lin HC.  Inactivation of mitochondrial pyruvate carrier promotes NLRP3 inflammasome activation and gout development via metabolic reprogramming. IMMUNOLOGY. Vol.169-No.3:271-291. Jul. 2023. (SCI/SCIE)
4. Chen LC, Huang SP, Shih CT, Li CY, Chen YT, Huang CY, Yu CC, Lin VC, Lee CH, Geng JH, Bao BY.  ATP8B1:Aprognostic prostate cancer biomarker identified via genetic analysis. PROSTATE. Vol.83(6):602-611. May. 2023. (SCI/SCIE)
5. Lin HC, Chung CH, Chen LC, Wang JY, Chen CC, Huang KY,  Tsai MH,  Chien WC, Lin HA.  Pioglitazone use increases risk of Alzheimer's disease in patients with type 2 diabetes receiving insulin. Scientific Reports. Vol.13:e6625. Apr. 2023. (SCI/SCIE)
6. Lu WJ, Tsai CH, Chen RJ, Huang LT, Chen TY, Chen LC, Wang HH, Peng HY, Sun YY, Lin KH.  Artesunate as a glycoprotein VI antagonist for preventing platelet activation and thrombus formation. BIOMEDICINE & PHARMACOTHERAPY. Vol.153:e113531. Sep. 2022. (SCI/SCIE)
7. Li RT, Lin HC, Chung CH, Lin HA, Wang JY, Chen LC, Huang KY, Sun CA, Chien WC, Chen CC.  Trichomonas infection in pregnant women: a nationwide cohort study. Parasitology Research. Vol.121(7):1973-1981. Jul. 2022. (SCI/SCIE)
8. Wang JY, Lin HC, Lin HA, Chung CH, Chen LC, Huang KY, Sun CA, Chien WC, Guo JL.  Associations between Diabetes Mellitus and Nontuberculous Mycobacterium-Caused Diseases in Taiwan: A Nationwide Cohort Study. American Journal of Tropical Medicine and Hygiene. Vol.105-No.6:1672-1679. Dec. 2021. (SCI/SCIE)
9. Huang PJ, Huang CY, Li YX, Liu YC, Chu LJ, Yeh YM, Cheng WH, Chen RM, Lee CC, Chen LC, Lin HC, Chiu SF, Lin WN, Lyu PC, Tang P, Huang KY.  Dissecting the Transcriptomes of Multiple Metronidazole-Resistant and Sensitive Trichomonas vaginalis Strains Identified Distinct Genes and Pathways Associated with Drug Resistance and Cell Death. Biomedicines. Vol.9-No.12:e1817. Dec. 2021. (SCI/SCIE)
10. Chiu SF, Huang PJ, Cheng WH, Huang CY, Chu LJ, Lee CC, Lin HC, Chen LC, Lin WN, Tsao CH, Tang P, Yeh YM, Huang KY.  Vaginal Microbiota of the Sexually Transmitted Infections Caused by Chlamydia trachomatis and Trichomonas vaginalis in Women with Vaginitis in Taiwan. Microorganisms. Vol.9-No.9:e1864. Sep. 2021. (SCI/SCIE)
11. Tsai YC, Huang CY, Hsueh YM, Fan YC, Fong YC, Huang SP, Geng JH, Chen LC, Lu TL, Bao BY.  Genetic variants in MAPK10 modify renal cell carcinoma susceptibility and clinical outcomes. LIFE SCIENCES. Vol.275:e119396. Jun. 2021. (SCI/SCIE)
12. Huang SP, Chen YT, Chen LC, Lee CH, Huang CY, Yu CC, Lin VC, Lu TL, Bao BY.  NRG1 Genetic Variant Influences the Efficacy of Androgen-Deprivation Therapy in Men with Prostate Cancer. Biomedicines. Vol.9(5):e528-e528. May. 2021. (SCI/SCIE)
13. Huang SP, Chen LC, Chen YT, Lee CH, Huang CY, Yu CC, Lin VC, Lu TL, Bao BY.  PTBP1 genetic variants affect the clinical response to androgen-deprivation therapy in patients with prostate cancer. Cancer Genomics & Proteomics. Vol.18(3):325-334. May. 2021. (SCI/SCIE)
14. Wang SH, Huang SP, Pan YJ, Hsiao PC, Li CY, Chen LC, Yu CC, Huang CY, Lin VC, Lu TL, Bao BY.  Association between the polygenic liabilities for prostate cancer and breast cancer with biochemical recurrence after radical prostatectomy for localized prostate cancer. American Journal of Cancer Research. Vol.11-No.5:2331-2342. May. 2021. (SCI/SCIE)
15. Lin HC, Chen YJ, Wei YH, Lin HA, Chen CC, Liu TF, Hsieh YL, Huang KY, Lin KH, Wang HH, Chen LC*.  Lactic acid fermentation is required for NLRP3 inflammasome activation. Frontiers in Immunology. Vol.12:e630380. Mar. 2021. (SCI/SCIE)
16. Huang CY, Huang SP, Hsueh YM, Chen LC, Lu TL, Bao BY.  Genetic analysis identifies the role of HLF in renal cell carcinoma. Cancer Genomics & Proteomics. Vol.17-No.6:827-833. Nov. 2020. (SCI/SCIE)
17. Lim KH, Chen LC, Hsu K, Chang CC, Chang CY, Kao CW, Chang YF, Chang MC, Chen C.  BAFF-driven NLRP3 inflammasome activation in B cells. Cell Death & Disease. Vol.11:e820-e820. Oct. 2020. (SCI/SCIE)
18. Lin HA, Chien WC, Huang KY, Chung CH, Chen LC, Lin HC, Guo JL.  Infection with Toxoplasma gondii increases the risk of psychiatric disorders in Taiwan: a nationwide population-based cohort study. PARASITOLOGY. Vol.147(13):1577-1586. Jul. 2020. (SCI/SCIE)
19. Lin HC, Chen YJ, Wei YH, Chuang YT, Hsieh SH, Hsieh YJ, Hsieh YL, Ojcius DM, Huang KY, Chung IC, Yuan SN, Chang YS, Chen LC*.  Cbl negatively regulates NLRP3 inflammasome activation through GLUT1-dependent glycolysis inhibition. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Vol.21-No.14:1-16. Jul. 2020. (SCI/SCIE)
20. Chang KH, Hsu YC, Chiu IM, Chen LC, Hsu CC, Lee CY, Fan HC, Chen HJ, Chou RH.  Association between Periodontitis and Bipolar Disorder: A Nationwide Cohort Study. MEDICINE. Vol.99-No.31:1-8. Jul. 2020. (SCI/SCIE)
21. Lin HC, Chu LJ, Huang PJ, Cheng WH, Zheng YH, Huang CY, Hong SW, Chen LC, Lin HA, Wang JY, Chen RM, Lin WN, Tang P, Huang KY.  Proteomic signatures of metronidazole‑resistant Trichomonas vaginalis reveal novel proteins associated with drug resistance. Parasites & Vectors. Vol.13:1-14. Jun. 2020. (SCI/SCIE)
22. Ke CC, Chen LC, Yu CC, Cheng WC, Huang CY, Lin VC, Lu TL, Huang SP, Bao BY.  Genetic analysis reveals a significant contribution of CES1 to prostate cancer progression in Taiwanese men. Cancers. Vol.12(5):e1346-e1346. May. 2020. (SCI/SCIE)
23. Hu SI, Ko MC, Dai YH, Lin HA, Chen LC, Huang KY, Pang TL, Kuo CY, Lin HC.  Pre-clinical assessment of chimeric antigen receptor T cell therapy targeting CD19+ B cell malignancy. Annals of Translational Medicine. Vol.8-No.9:1-11. May. 2020. (其他具同儕審查機制之期刊)
24. Yu CC, Chen LC, Lin WH, Lin VC, Huang CY, Lu TL, Lee CH, Huang SP, Bao BY.  Genetic Association Analysis of Cell Cycle Regulators Reveals YWHAZ Has Prognostic Significance in Prostate Cancer. Cancer Genomics & Proteomics. Vol.17(2):209-216. Mar. 2020. (SCI/SCIE)
25. Yu CC, Chen LC, Huang CY, Lin VC, Lu TL, Lee CH, Huang SP, Bao BY.  Genetic association analysis identifies a role for ANO5 in prostate cancer progression. Cancer Medicine. Vol.9(7):2372-2378. Feb. 2020. (SCI/SCIE)
26. Chung IC, Chen LC, Tsang NM, Chuang WY, Liao TC, Yuan SN, OuYang CN, Ojcius DM, Wu CC, Chang YS.  Mitochondrial oxidative phosphorylation complex regulates NLRP3 inflammasome activation and predicts patient survival in nasopharyngeal carcinoma. MOLECULAR & CELLULAR PROTEOMICS. Vol.19-No.1:142-154. Jan. 2020. (SCI/SCIE)
27. Chung IC, Yuan SN, OuYang CN, Hu SI, Lin HC, Huang KY, Lin WN, Chuang YT, Chen YJ, Ojcius DM, Chang YS, Chen LC*.  EFLA 945 restricts AIM2 inflammasome activation by preventing DNA entry for psoriasis treatment. CYTOKINE. Vol.127:1-9. Dec. 2019. (SCI/SCIE)
28. Lee CH, Chen LC, Yu CC, Lin WH, Lin V, Huang CU, Lu TL, Huang SP, Bao BY.  Prognostic value of CD1B in localised prostate cancer. International Journal of Environmental Research and Public Health. Vol.16-No.23:1-8. Nov. 2019. (其他具同儕審查機制之期刊)
29. Chung AK, OuYang CN, Liu H, Chao M, Luo JD, Lee CY, Lu YJ, Chung IC, Chen LC, Wu SM, Tsang NM, Chang KP, Hsu CL, Li HP, Chang YS.  Targeted sequencing of cancer‐related genes in nasopharyngeal carcinoma identifies mutations in the TGF‐β pathway. Cancer Medicine. Vol.8-No.11:5116-5127. Jul. 2019. (SCI/SCIE)
30. Yu CC, Chen LC, Lin VCH, Huang CY, Cheng WC, Hsieh AR, Chang TY, Lu TL, Lee CH, Huang SP, Bao BY.  Effect of genetic variants in cell adhesion pathways on the biochemical recurrence in prostate cancer patients with radical prostatectomy. Cancer Medicine. Vol.8-No.6:2777-2783. Jun. 2019. (SCI/SCIE)
31. Yu CC, Chen LC, Chiou CY, Chang YJ, Lin VC, Huang CY, Lin IL, Chang TY, Lu TL, Lee CH, Huang SP, Bao BY.  Genetic variants in the circadian rhythm pathway as indicators of prostate cancer progression. Cancer Cell International. Vol.19:e87. Apr. 2019. (SCI/SCIE)
32. Chung IC, OuYang CN, Yuan SN, Lin HC, Huang KY, Wu PS, Liu CY, Tsai KJ, Loi LK, Chen YJ, Chung AK, Ojcius DM, Chang YS, Chen LC*.  Pretreatment with a heat-killed probiotic modulates the NLRP3 inflammasome and attenuates colitis-associated colorectal cancer in mice. Nutrients. Vol.11-No.3:1-16. Feb. 2019. (SCI/SCIE)
33. Huang CY, Hsueh YM, Chen LC, Cheng WC, Yu CC, Chen WJ, Lu TL, Lan KJ, Lee CH, Huang SP, Bao BY.  Clinical significance of glutamate metabotropic receptors in renal cell carcinoma risk and survival. Cancer Medicine. Vol.7-No.12:6104-6111. Nov. 2018. (SCI/SCIE)
34. Chung IC, Yuan SN, OuYang CN, Lin HC, Huang KY, Chen YJ, Chung AK, Chu CL, Ojcius DM, Chang YS, Chen LC*.  Src-family kinase-Cbl axis negatively regulates NLRP3 inflammasome activation. Cell Death & Disease. Vol.9:1-14. Oct. 2018. (SCI/SCIE)
35. Chung IC, OuYang CN, Yuan SN, Li HP, Chen JT, Shieh HR, Chen YJ, Ojcius DM, Chu CL, Yu JS, Chang YS, Chen LC*.  Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasomedependent peritonitis. Scientific Reports. Vol.6:1-13. Oct. 2016. (SCI/SCIE)
36. Wu CS, Chang KP, OuYang CN, Kao HK, Hsueh C, Chen LC, Cheng HY, Liang Y, Liou W, Liang CL, Chang YS.  ASC Contributes to Metastasis of Oral Cavity Squamous Cell Carcinoma. Oncotarget. Vol.7-No.25:50074-50085. Jun. 2016. (SCI)
37. Tai YL, Chen LC, Shen TL.  Emerging Roles of Focal Adhesion Kinase in Cancer. BioMed Research International. Vol.2015:1-13. Mar. 2015. (SCI)
38. Chung IC, Chen LC, Chung AK, Chao M, Huang HY, Hsueh C, Tsang NM, Chang KP, Liang Y, Li HP, Chang YS.  Matrix Metalloproteinase 12 Is Induced by Heterogeneous Nuclear Ribonucleoprotein K and Promotes Migration and Invasion in Nasopharyngeal Carcinoma. BMC Cancer. Vol.14:348-361. May. 2014. (SCI)
39. Huang SP, Lévesque E, Guillemette C, Yu CC, Huang CY, Lin VC, Chung IC, Chen LC, Laverdière I, Lacombe L, Fradet Y, Chang TY, Lee HZ, Juang SH, Bao BY.  Genetic variants in microRNAs and microRNA target sites predict biochemical recurrence after radical prostatectomy in localized prostate cancer. International Journal of Cancer. Vol.134-No.10:2284-2293. May. 2014. (SCI)
40. Chen LC, Wang LJ, Tsang NM, Ojcius DM, Chen CC, OuYang CN, Hsueh C, Liang Y, Chang KP, Chen CC, Chang YS.  Tumor inflammasome-derived IL-1β recruits neutrophils and improves local recurrence-free survival in EBV-induced nasopharyngeal carcinoma patients. EMBO Molecular Medicine. Vol.4(12):1276-1293. Dec. 2012. (SCI)
41. Wang LJ, Hsu CW, Chen CC, Liang Y, Chen LC, Ojcius DM, Tsang NM, Hsueh C, Wu CC, Chang YS.  Interactome-wide analysis identifies End-Binding Protein 1 as a crucial component for the speck-like particle formation of activated AIM2 inflammasomes. Molecular & Cellular Proteomics. Vol.11(11):1230-1244. Nov. 2012. (SCI)
42. Wu CS, Chang KP, Chen LC, Chen CC, Liang Y, Hseuh C, Chang YS.  Heterogeneous ribonucleoprotein K and thymidine phosphorylase are independent prognostic and therapeutic markers for oral squamous cell carcinoma. Oral Oncology. Vol.48:516-522. Jun. 2012. (SCI)
43. Lee CM, Yang P, Chen LC, Chen CC, Wu SC, Cheng HY, Chang YS.  A Novel Role of RASSF9 in Maintaining Epidermal Homeostasis. PLoS One. Vol.6(3):1-21. Mar. 2011. (SCI)
44. Chen LC, Chen CC, Liang Y, Tsang NM, Chang YS, Hsueh C.  A novel role for TNFAIP2: its correlation with invasion and metastasis in nasopharyngeal carcinoma. Modern Pathology. Vol.24(2):175-84. Feb. 2011. (SCI)
45. Chen LC, Chung IC, Hsueh C, Tsang NM, Chi LM, Liang Y, Chen CC, Wang LJ, Chang YS.  The antiapoptotic protein, FLIP, is regulated by heterogeneous nuclear ribonucleoprotein K and correlates with poor overall survival of nasopharyngeal carcinoma patients. Cell Death and Differentiation. Vol.17(9):1463-1473. Sep. 2010. (SCI)
46. Chen CC, Chen LC, Liang Y, Tsang NM, Chang YS.  Epstein-Barr virus latent membrane protein 1 induces the chemotherapeutic target, thymidine phosphorylase, via NF-kappaB and p38 MAPK pathways. Cellular Signalling. Vol.22(7):1132-1142. Jul. 2010. (SCI)
47. Chiang CW, Huang Y, Leong KW, Chen LC, Chen HC, Chen SJ, Chou CK.  PKCα mediated induction of miR-101 in human hepatoma HepG2 cells. Journal of Biomedical Science. Vol.17:35:1-9. May. 2010. (SCI)
48. Lu YJ, Wu CS, Li HP, Lu CY, Leu YW, Wang CS, Chen LC, Lin KH, Chang YS.  Aberrant methylation impairs low density lipoprotein receptor-related protein 1B tumor suppressor function in gastric cancer. Genes Chromosomes and Cancer. Vol.49(5):412-424. May. 2010. (SCI)
49. Lu CY, Hsieh SY, Lu YJ, Wu CS, Chen LC, Lo SJ, Wu CT, Chou MY, Huang TH, Chang YS.  Aberrant DNA Methylation Profile and Frequent Methylation of KLK10 and OXGR1 Genes in Hepatocellular Carcinoma. Genes, Chromosomes and Cancer. Vol.48(12):1057-1068. Dec. 2009. (SCI)
50. Tse KP, Su WH, Chang KP, Tsang NM, Yu CJ, Tang P, See LC, Hsueh C, Yang ML, Hao SP, Li HY, Wang MH, Liao LP, Chen LC, Lin SR, Jorgensen TJ, Chang YS, Shugart YY.  Genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the HLA region at chromosome 6p21.3. American Journal of Human Genetics. Vol.85(2):194-203. Aug. 2009. (SCI)
51. Chen LC, Liu HP, Li HP, Hsueh C, Yu JS, Liang CL, Chang YS.  Thymidine phosphorylase mRNA stability and protein levels are increased through ERK-mediated cytoplasmic accumulation of hnRNP K in nasopharyngeal carcinoma cells. Oncogene. Vol.28(17):1904-1915. Apr. 2009. (SCI)
52. Chen LC, Hsueh C, Tsang NM, Liang Y, Chang KP, Hao SP, Yu JS, Chang YS.  Heterogeneous ribonucleoprotein K and thymidine phosphorylase are independent prognostic and therapeutic markers for nasopharyngeal carcinoma. Clinical Cancer Research. Vol.14(12):3807-3813. Jun. 2008. (SCI)

1. 黃琦甯， 林信仲， 陳立強*。  生物醫學聯合年會. 生物醫學聯合年會. 3月 2022.
2. 劉澤範， 林信仲， 陳立強*。  乳酸是一個 NLRP3 發炎體活化的關鍵介導因子. 過敏免疫聯合年會. 10月 2021.
3. 陳立強*。  建構實作與理論整合的微生物及免疫學課程. 108年度教育學門暨醫護學門計畫成果交流會. 8月 2020.
4. Chen LC*。  Regulation of inflammasome activation in nasopharyngeal. 國衛院暨中研院生醫所合辦年度免疫研討會. 11月 2013.
5. Chen LC， Chang YS。  以抑制核醣核酸蛋白粒之K蛋白(hnRNP K)或胸苷磷酸化酶 (TP)表現之化合物、及其小干擾核醣核酸序列作為癌症輔助治療(auxiliary therapy). 生物檢測與健康照護資訊之技術成果分享會. 3月 2013.
6. Lih-Chyang Chen, Li-Jei Wang, Nang-Ming Tsang, David M. Ojcius, Yu-Sun Chang.  Role of the AIM2 Inflammasome in Nasopharyngeal Carcinoma. Immunology 2011. May. 2011.
7. Lih-Chyang Chen， Yu-Sun Chang。  胸苷磷酸化酶受hnRNP K調控之研究及與鼻咽癌癒後之相關性. 前瞻性生物醫學暨科學新知研討會. 8月 2009.
8. Lih-Chyang Chen, Chuen Hsueh, Yu-Sun Chang.  Mechanistic study of interleukin-8 regulation in immune cell-infiltrated nasopharyngeal carcinoma. Pattern Recognition Molecules and Immune Sensors of Pathogens. Mar. 2009.
9. Lih-Chyang Chen, Chuen Hsueh, Ngan-Ming Tsang, Ying Liang, Kai-Ping Chang, Sheng-Po Hao, Jau-Song Yu, Yu-Sun Chang.  Heterogeneous nuclear ribonucleoprotein K and thymidine phosphorylase are independent prognostic and therapeutic markers for nasopharyngeal carcinoma. EBV conference 2008. Nov. 2008.

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lihchyang@mmu.edu.tw