台北醫學大學 醫學科學研究所 博士 (2009/06)

馬偕醫學院研究發展處 學術研究組組長

馬偕醫學院 生物醫學研究所 專任助理教授 (2018/08-2020/07)

台北醫學大學 藥理學科 兼任助理教授 (2013/10-迄今)

新光醫院 教學研究部中央研究室 研究員 (2011/07-2018/07)

中央研究院 生物醫學研究所 博士後研究學者 (2010/08-2011/06) 

藥理學、心血管藥理學

心血管疾病、中草藥、訊息傳遞

1. Hsieh MC, Lai CY, Cho WL, Lin LT, Yeh CM, Yang PS, Cheng JK, Wang HH, Lin KH, Nie ST, Lin TB, Peng HY.  Phosphate NIMA-Related Kinase 2-Dependent Epigenetic Pathways in Dorsal Root Ganglion Neurons Mediates Paclitaxel-Induced Neuropathic Pain. ANESTHESIA AND ANALGESIA. Vol.137-No.6:1289-1301. Dec. 2023. (SCI/SCIE)
2. Hsieh MC, Lai CY, Lin LT, Chou D, Yeh CM, Cheng JK, Wang HH, Lin KH, Lin TB, Peng HY.  Melatonin Relieves Paclitaxel-Induced Neuropathic Pain by Regulating pNEK2-Dependent Epigenetic Pathways in DRG Neurons. ACS Chemical Neuroscience. Vol.14:4227-4239. Dec. 2023. (SCI/SCIE)
3. Lai YW, Wang SW, Lin CL, Chen SS, Lin KH, Lee YT, Chen WC, Hsieh YH.  Asiatic acid exhibits antimetastatic activity in human prostate cancer cells by modulating the MZF-1/Elk-1/Snail signaling axis. EUROPEAN JOURNAL OF PHARMACOLOGY. Vol.951:e175770. Jul. 2023. (SCI/SCIE)
4. Hsieh MC, Lai CY, Yeh CM, Yang PS, Cheng JK, Wang HH, Lin KH, Nie ST, Lin TB, Peng HY.  Phosphorylated Upstream Frameshift 1-dependent Nonsense-mediated μ-Opioid Receptor mRNA Decay in the Spinal Cord Contributes to the Development of Neuropathic Allodynia-like Behavior in Rats. ANESTHESIOLOGY. Vol.138-No.6:634-655. Jun. 2023. (SCI/SCIE)
5. Lin KH, Li JY, Chen RJ, Chen TY, Hsu SH, Wang HH, Peng HY, Sun YY, Lu WJ.  Paclitaxel exerts antiplatelet and antithrombotic activities: Additional benefit from use of paclitaxel-coated balloons and -eluting stents in coronary revascularization and prevention of in-stent restenosis. THROMBOSIS RESEARCH. Vol.225:63-72. May. 2023. (SCI/SCIE)
6. Lu WJ, Tsai CH, Chen RJ, Huang LT, Chen TY, Chen LC, Wang HH, Peng HY, Sun YY, Lin KH*.  Artesunate as a glycoprotein VI antagonist for preventing platelet activation and thrombus formation. BIOMEDICINE & PHARMACOTHERAPY. Vol.153:e113531. Sep. 2022. (SCI/SCIE)
7. Lai CY, Hsieh MC, Yeh CM, Yang PS, Cheng JK, Wang HH, Lin KH, Nie ST, Lin TB, Peng HY.  MicroRNA-489-3p attenuates neuropathic allodynia by regulating oncoprotein DEK/TET1-dependent epigenetic modification in the dorsal horn. NEUROPHARMACOLOGY. Vol.210:e109028. Jun. 2022. (SCI/SCIE)
8. Tzu-Yin Lee, Wan-Jung Lu, Chun A. Changou, Yuan-Chin Hsiung, Nguyen T. T. Trang, Cheng-Yang Lee, Tzu-Hao Chang, Thanasekaran Jayakumar, Cheng- Ying Hsieh, Chih-Hao Yang, Chao-Chien Chang, Ray-Jade Chen, Joen-Rong Sheu, Kuan-Hung Lin*.  Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism. Autophagy. Vol.17(12):4141-4158. Dec. 2021. (SCI/SCIE)
9. Shih TL, Lin KH, Chen RJ, Chen TY, Kao WT, Liu JW, Wang HH, Peng HY, Sun YY, Lu WJ.  A novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. Vol.25(19):9434-9446. Oct. 2021. (SCI/SCIE)
10. Lien LM, Lu WJ, Lin KH, Kang LH, Chen TY, Lin BJ, Lu YC, Huang CY, Shih CM, Chen H, Tsai YC, Chen RJ, Sheu JR.  Influence of Vincristine, Clinically Used in Cancer Therapy and Immune Thrombocytopenia, on the Function of Human Platelets. MOLECULES. Vol.26(17):e5340. Sep. 2021. (SCI/SCIE)
11. Lin HC, Chen YJ, Wei YH, Lin HA, Chen CC, Liu TF, Hsieh YL, Huang KY, Lin KH, Wang HH, Chen LC.  Lactic Acid Fermentation Is Required for NLRP3 Inflammasome Activation. Frontiers in Immunology. Vol.12:e630380. Mar. 2021. (SCI/SCIE)
12. Lien LM, Lu WJ, Chen TY, Lee TY, Wang HH, Peng HY, Chen RJ, Lin KH*.  Phospholipase D1 and D2 Synergistically Regulate Thrombus Formation.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Vol.21:6954-6954. Sep. 2020. (SCI/SCIE)
13. Lu WJ, Li JY, Chen RJ, Huang LT, Lee TY, Lin KH*.  VAS2870 and VAS3947 attenuate platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC. Scientific Reports. Vol.9:1-13. Dec. 2019. (SCI/SCIE)
14. Ching-Yi Chen, Po-Lin Liao, Chi-Hao Tsai, Yen-Ju Chan, Yu-Wen Cheng, Ling-Ling Hwang, Kuan-Hung Lin, Ting-Ling Yen, Ching-Hao Li.  Inhaled gold nanoparticles cause cerebral edema and upregulate endothelial aquaporin 1 expression, involving caveolin 1 dependent repression of extracellular regulated protein kinase activity. Particle and Fibre Toxicology. Vol.16:1-13. Oct. 2019. (SCI/SCIE)
15. Jiun Yi Li, Ray Jade Chen, Li Ting Huang, Tzu Yin Lee, Wan Jung Lu, Lin KH*.  Embelin as a Novel Inhibitor of PKC in the Prevention of Platelet Activation and Thrombus Formation. Journal of Clinical Medicine. Vol.8:1-16. Oct. 2019. (SCI/SCIE)
16. Hou SM, Hsia CH, Velusamy M, Jayakumar T, Hsia CW, Chang CC, Lin KH, Lu YC.  Ruthenium complex, TQ‑5, protects against LPS‑induced macrophage inflammation and acute liver injury in mice via downregulating NF‑κB pathways. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. Vol.44:335-345. Jul. 2019. (SCI/SCIE)
17. Lu WJ, Lin KH, Tseng MF, Yuan KC, Huang HC, Sheu JR, Chen RJ.  New therapeutic strategy of hinokitiol in haemorrhagic shock‐induced liver injury. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. Vol.23:1723-1734. Mar. 2019. (SCI/SCIE)
18. Wan Jung Lu, Chi Li Chung, Ray Jade Chen, Li Ting Huang, Li Ming Lien, Chao Chien Chang, Kuan Hung Lin*, Joen Rong Sheu.  An antithrombotic strategy by targeting phospholipase D in human platelets. Journal of Clinical Medicine. Vol.7:440-440. Nov. 2018. (SCI/SCIE)
19. Lu WJ, Wu GJ, Chen RJ, Chang CC, Lien LM, Chiu CC, Tseng MF, Huang LT, Lin KH*.  Licochalcone A attenuates glioma cell growth in vitro and in vivo through cell cycle arrest. Food & Function. Vol.9:4500-4507. Aug. 2018. (SCI/SCIE)
20. Chih-Hsuan Hsia, Wan-Jung Lu, Kuan-Hung Lin, Duen-Suey Chou, Pitchairaj Geraldine, Thanasekaran Jayakuma, Nen-Chung Chang, Joen-Rong Sheu.  Norcantharidin, a clinical used chemotherapeutic agent, acts as a powerful inhibitor by interfering with fibrinogen-integrin αIIb β3 binding in human platelets. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. Vol.22:2142-2152. Apr. 2018. (SCI/SCIE)
21. Hsia CH, Velusamy M, Sheu JR, Khamrang T, Jayakumar T, Lu WJ, Lin KH, Chang CC.  A novel ruthenium (II)-derived organometallic compound, TQ-6, potently inhibits platelet aggregation: Ex vivo and in vivo studies. Scientific Reports. Vol.7:9556-9556. Aug. 2017. (SCI/SCIE)
22. Lien LM, Lin KH, Huang LT, Tseng MF, Chiu HC, Chen RJ, Lu WJ.  Licochalcone A Prevents Platelet Activation and Thrombus Formation through the Inhibition of PLCγ2-PKC, Akt, and MAPK Pathways. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Vol.18:1500-1500. Jul. 2017. (SCI/SCIE)
23. Lee TY, Chang CC, Lu WJ, Yen TL, Lin KH, Geraldine P, Li JY, Sheu JR.  Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies. Scientific Reports. Vol.7:40002-40002. Jan. 2017. (SCI/SCIE)
24. Yen TL, Chen RJ, Jayakumar T, Lu WJ, Hsieh CY, Hsu MJ, Yang CH, Chang CC, Lin YK, Lin KH*, Sheu JR.  Andrographolide stimulates p38 mitogen-activated protein kinase-nuclear factor erythroid-2-related factor 2-heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats. Translational Research. Vol.170:57-72. Apr. 2016. (SCI/SCIE)
25. Lien LM, Wang MJ, Chen RJ, Chiu HC, Wu JL, Shen MY, Chou DS, Sheu JR, Lin KH*, Lu WJ.  Nobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways. PHYTOTHERAPY RESEARCH. Vol.30:214-221. Feb. 2016. (SCI/SCIE)
26. Lin KH, Lin KC, Lu WJ, Thomas PA, Jayakumar T, Sheu JR.  Astaxanthin, a Carotenoid, Stimulates Immune Responses by Enhancing IFN-γ and IL-2 Secretion in Primary Cultured Lymphocytes in Vitro and ex Vivo. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Vol.17-No.1:1-10. Jan. 2016. (SCI/SCIE)
27. Lu WJ, Chang CC, Lien LM, Yen TL, Chiu HC, Huang SY, Sheu JR, Lin KH*.  Xanthohumol from Humulus lupulus L. induces glioma cell autophagy via inhibiting Akt/mTOR/S6K pathway. Journal of Functional Foods. Vol.18:538-549. Sep. 2015. (SCI)
28. Chung CL, Leung KW, Lu WJ, Yen TL, He CF, Sheu JR, Lin KH*, Lien LM.  Hinokitiol Negatively Regulates Immune Responses through Cell Cycle Arrest in Concanavalin A-Activated Lymphocytes. Evidence-Based Complementary and Alternative Medicine. Vol.2015:59582-59582. Aug. 2015. (SCI)
29. Chang Y, Hsu WH, Lu WJ, Jayakumar T, Liao JC, Lin MJ, Wang SH, Geraldine P, Lin KH*, Sheu JR.  Inhibitory mechanisms of CME-1, a novel polysaccharide from the mycelia of Cordyceps sinensis, in platelet activation. Current Pharmaceutical Biotechnology. Vol.16:451-461. Mar. 2015. (SCI)
30. Lien LM, Chen ZC, Chung CL, Yen TL, Chiu HC, Chou DS, Huang SY, Sheu JR, Lu WJ, Lin KH*.  Multidrug resistance protein 4 (MRP4/ABCC4) regulates thrombus formation in vitro and in vivo. European Journal of Pharmacology. Vol.737:159-167. Aug. 2014. (SCI)
31. Lin KH, Lu WJ, Wang SH, Fong TH, Chou DS, Chang CC, Chang NC, Chiang YC, Huang SY, Sheu JR.  Characteristics of endogenous γ-aminobutyric acid (GABA) in human platelets: functional studies of a novel collagen glycoprotein VI inhibitor. Journal of Molecular Medicine. Vol.27:1671-1677. Jun. 2014. (SCI)
32. Lu WJ, Lin KC, Huang SY, Thomas PA, Wu YH, Wu HC, Lin KH*, Sheu JR.  Role of a Janus kinase 2-dependent signaling pathway in platelet activation. Thrombsis Research. Vol.133:1088-1096. Jun. 2014. (SCI)
33. Ting-Lin Yen, Wan-Jung Lu, Li-Ming Lien, Philip Aloysius Thomas, Tzu-Yin Lee, Hou-Chang Chiu, Joen-Rong Sheu, Kuan-Hung Lin*.  Amarogentin, a secoiridoid glycoside, abrogates platelet activation through PLC γ 2-PKC and MAPK pathways. Biomed Research International. Vol.2014:72801-72801. Apr. 2014. (SCI)
34. Wan-Jung Lu, Ming-Ping Wu, Kuan-Hung Lin, Yu-Chen Lin, Hsiu-Chu Chou, Joen-Rong Sheu.  Hinokitiol is a novel glycoprotein VI antagonist on human platelets. Platelets. Vol.25:595-602. Jan. 2014. (SCI)
35. Lien LM, Su CC, Hsu WH, Lu WJ, Chung CL, Yen TL, Chiu HC, Sheu JR, Lin KH*.  Mechanisms of Andrographolide-Induced Platelet Apoptosis in Human Platelets: Regulatory Roles of the Extrinsic Apoptotic Pathway. Phytotherapy Research. Vol.27:1671-1677. Nov. 2013. (SCI)
36. Lin KH, Kuo JR, Lu WJ, Chung CL, Chou DS, Huang SY, Lee HC, Sheu JR.  Hinokitiol inhibits platelet activation ex vivo and thrombus formation in vivo. Biochemical Pharmacology. Vol.85:1478-1485. May. 2013. (SCI)
37. Lu WJ, Lin KH, Hsu MJ, Chou DS, Hsiao G, Sheu JR.  Suppression of NF-κB signaling by andrographolide with a novel mechanism in human platelets: regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade. Biochemical Pharmacology. Vol.84:914-924. Oct. 2012. (SCI)
38. Lee YM, Hsieh KH, Lu WJ, Chou HC, Chou DS, Lien LM, Sheu JR, Lin KH*.  Xanthohumol, a Prenylated Flavonoid from Hops (Humulus lupulus), Prevents Platelet Activation in Human Platelets. Evidence-Based Complementary and Alternative Medicine. Vol.2012:85236-85236. May. 2012. (SCI)
39. Lin KH, Chang YF, Fan CY, Jayakumar T, Lee JJ, Chou DS, Hsiao G, Sheu JR.  Arsenic trioxide-mediated antiplatelet activity: pivotal role of the phospholipase C gamma 2-protein kinase C-p38 MAPK cascade. Translational Research. Vol.155:97-108. Feb. 2010. (SCI)
40. Lin KH, Chang HC, Lu WJ, Jayakumar T, Chou HC, Fong TH, Hsiao G, Sheu JR.  Comparison of the relative activities of inducing platelet apoptosis stimulated by various platelet-activating agents.. Platelets. Vol.20:575-581. Dec. 2009. (SCI)
41. Lin KH, Hsiao G, Shih CM, Chou DS, Sheu JR.  Mechanisms of resveratrol-induced platelet apoptosis. Cardiovascular Research. Vol.83:575-585. Aug. 2009. (SCI)

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